How SUBLOCADE works
SUBLOCADE is delivered continuously at a sustained level throughout the month.
Knowing how SUBLOCADE works and why the medicine used in it, buprenorphine, is different from other opioids is important.
SUBLOCADE is injected by a treatment provider as a liquid and, once inside the body, turns to a solid gel called a depot (dee-poh).
The depot gradually releases buprenorphine at a controlled rate all month.
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Sustained levels throughout the month
Buprenorphine is delivered at sustained levels. This means that the levels of buprenorphine in the blood stay consistent throughout the month. The chart below shows what the levels look like during treatment with once-monthly SUBLOCADE.
In a study of buprenorphine plasma levels
How the study was conducted
Throughout the study, levels of buprenorphine were measured in patients’ blood. Patients started with a required preliminary period on daily oral buprenorphine (under the tongue or inside the cheek) to control withdrawal symptoms. After patients were stabilized, they were transitioned to treatment with once-monthly SUBLOCADE. The buprenorphine levels peaked within 24 hours, then decreased to a level that was maintained throughout the month.This data was gathered during a 12-week study designed to measure if SUBLOCADE 300 mg blocked the subjective effects of opioids (hydromorphone 6 mg or 18 mg) in 39 patients. The graph represents modeled measurements and not actual treatment. SUBLOCADE data was not collected daily. Individual results may vary. Before starting treatment with SUBLOCADE, patients must be stabilized for at least 7 days on transmucosal buprenorphine.
How SUBLOCADE blocks the rewarding
effects of opioids*
When the medicine in SUBLOCADE, buprenorphine, attaches to receptors in the brain other opioids are less likely to attach.
While on SUBLOCADE, a person will receive a continuous delivery of buprenorphine all month.
*In a 12-week study of 39 non-treatment-seeking adults, SUBLOCADE blocked the rewarding effects of opioids.
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Save on SUBLOCADE
For most people with insurance SUBLOCADE is covered.
Check with your insurance provider for more details.
What’s the most important information to know about SUBLOCADE?
Because of the serious risk of potential harm or death from self-injecting SUBLOCADE into a vein (intravenously), it is only available through a restricted program called the SUBLOCADE REMS Program.
In an emergency, you or your family should tell the emergency medical staff that you are physically dependent on an opioid and are being treated with SUBLOCADE.
Buprenorphine, the medicine in SUBLOCADE, can cause serious and life-threatening problems, especially if you take or use certain other medicines or drugs. Call your healthcare provider right away or get emergency help if you:
- feel faint or dizzy
- have mental changes such as confusion
- have slower breathing than you normally have
- have severe sleepiness
- have blurred vision
- have problems with coordination
- have slurred speech
- cannot think well or clearly
- have a high body temperature
- have slowed reflexes
- feel agitated
- have stiff muscles
- have trouble walking
These can be signs of an overdose or other serious problems.
Death or serious harm, including life-threatening breathing problems, can happen if you take anxiety medicines or benzodiazepines, sleeping pills, tranquilizers, muscle relaxants, or sedatives, antidepressants, or antihistamines, or drink alcohol during treatment with SUBLOCADE. Tell your healthcare provider if you are taking any of these medicines and if you drink alcohol.
Call your healthcare provider for medical advice about side effects. You may also report side effects to the FDA at 1-800-FDA-1088.