Get ready for treatment

What to expect

There are 2 phases to starting SUBLOCADE.

Once you and your treatment provider have decided that SUBLOCADE is right for you, treatment can begin.


Before receiving SUBLOCADE, you’ll need to take a daily transmucosal form of buprenorphine (under the tongue or inside the cheek) for at least 7 days to help control withdrawal symptoms. Make sure your follow-up appointment is scheduled.


SUBLOCADE will be administered in an office by your treatment provider after you complete induction.

People who have Opioid Use Disorder have an elevated risk for opioid overdose. Talk to your healthcare provider about naloxone. Naloxone is a medicine that is available to patients for emergency treatment of an opioid overdose. It is not a treatment for Opioid Use Disorder.

What to expect during the appointment

Your treatment provider will administer SUBLOCADE

The injection is given just under the skin (subcutaneous) in your abdomen.

You may feel or see a small bump

A small bump under your skin at the injection site for several weeks is normal. The bump is called a depot, which releases medicine throughout the month. Over time, as medication is released into your body, the bump will get smaller. See how the depot works.

Talk to your treatment provider if you have questions about the size of the bump.

Do not try to remove the depot, and do not rub or massage the injection site. Likewise, try not to let belts or waistbands rub against the injection site.

Find a SUBLOCADE treatment provider

For more information on how to find a facility, call INSUPPORT® at 1-844-467-7778.

What to know about dosing

SUBLOCADE comes in 2 doses: 300 mg and 100 mg. You’ll receive a dose once a month (with at least 26 days between doses).

Your treatment provider will start with 300 mg to help the medication reach an effective level in your body. After 2 months, many will receive a lower dose of 100 mg. Some will stay on 300 mg. Your treatment provider will decide what's best. Learn more about how SUBLOCADE sustains medication levels in your body.

If you miss a dose, see your treatment provider as soon as possible.

The level of medicine in your blood is important. Ask your treatment provider about how the delivery system used in SUBLOCADE maintains medicine levels even when the dose is lowered (e.g., from 300 mg to 100 mg on month 3).

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Stay committed

It may take time for your brain to reset and for you to make healthy changes. Be patient and stay with your treatment plan. Don’t give up.

If you experience a slip-up and use illicit opioids while on SUBLOCADE, talk to your treatment provider. Because buprenorphine blocks the rewarding effects of opioids,* continued opioid use can become less appealing.

The journey towards recovery is different for everyone. Some people may experience relapse. If this happens to you, treatment can be restarted. You can keep moving towards recovery.

Tell your treatment provider about your goals, so you can work together to decide the length of treatment.

*In a 12-week study of 39 non-treatment-seeking adults, SUBLOCADE blocked the rewarding effects of opioids.


For most people with insurance, SUBLOCADE is covered. Check with your insurance provider for more details.

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What is the most important information I should know about SUBLOCADE?

Because of the serious risk of potential harm or death from self-injecting SUBLOCADE into a vein (intravenously), it is only available through a restricted program called the SUBLOCADE REMS Program.

SUBLOCADE contains a medicine called buprenorphine. Buprenorphine is an opioid that can cause serious and life-threatening breathing problems, especially if you take or use certain other medicines or drugs.

Talk to your healthcare provider about naloxone. Naloxone is a medicine that is available to patients for the emergency treatment of an opioid overdose. If naloxone is given, you must call 911 or get emergency medical help right away to treat overdose or accidental use of an opioid.

SUBLOCADE may cause serious and life‐threatening breathing problems. Get emergency help right away if you:

Do not take certain medicines during treatment with SUBLOCADE. Taking other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) while on SUBLOCADE can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.

In an emergency, have family members tell emergency department staff that you are physically dependent on an opioid and are being treated with SUBLOCADE.

You may have detectable levels of SUBLOCADE in your body for a long period after stopping treatment with SUBLOCADE.

Death has been reported in those who are not opioid dependent who received buprenorphine sublingually.

Who should not take SUBLOCADE?

Do not use SUBLOCADE if you are allergic to buprenorphine or any ingredient in the prefilled syringe (Indivior's proprietary buprenorphine gel depot delivery system, a biodegradable 50:50 poly(DL-lactide-co-glycolide) polymer and a biocompatible solvent, N-methyl-2-pyrrolidone (NMP)).

Before starting SUBLOCADE, tell your healthcare provider about all of your medical conditions, including if you have:

Tell your healthcare provider if you are:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

What should I avoid while being treated with SUBLOCADE?

What are the possible side effects of SUBLOCADE?

SUBLOCADE can cause serious side effects, including:

These are not all the possible side effects. Call your healthcare provider for medical advice about side effects.

To report a pregnancy or side effects associated with taking SUBLOCADE or any safety related information, product complaint, request for medical information, or product query, please contact or 1-877-782-6966. You are encouraged to report negative side effects of drugs to the FDA. Visit or call 1-800-FDA-1088.

See full Prescribing Information, including BOXED WARNING, and Medication Guide. For REMS information visit